Gonadorelin Acetate

Important Statement: This product is a high-purity synthetic peptide research reagent, strictly for in vitro research use only (For Research Use Only). It is the active pharmaceutical ingredient (API) of an approved drug but is not sold here as a pharmaceutical product. Any use in humans, clinical diagnosis, drug formulation, healthcare, fitness, or any other non-research purpose is strictly prohibited. The purchaser must be a qualified professional researcher and operate in a laboratory environment that complies with all regulations.

1. Product Overview
This product, Gonadorelin Acetate, is a synthetic decapeptide analog of Gonadotropin-Releasing Hormone (GnRH). Serving as a core tool for studying signal transduction in the hypothalamic-pituitary-gonadal (HPG) axis, it is supplied in its acetate salt form as a white lyophilized powder. With high purity and stability, it is specifically prepared for rigorous in vitro research in endocrinology, reproductive biology, and receptor pharmacology mechanisms.

2. Key Features

• High Purity Standard: Verified by High-Performance Liquid Chromatography (HPLC) analysis, with a purity of ≥ 98%.

• Defined Structure and Sequence: Precise molecular weight and amino acid sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) are provided to ensure research reproducibility.

• Rigorous Quality Control: Subjected to sterility testing and low endotoxin levels (<1.0 EU/mg), meeting research reagent standards.

• Stable Formulation: Lyophilized powder form, recommended for long-term storage in a dry, dark environment at -20°C.

3. Primary Research Applications (Examples)

• Receptor Signal Transduction Studies: Used for the in vitro evaluation of its binding affinity to the GnRH receptor, internalization processes, and mechanisms of activating downstream IP3/DAG and calcium ion signaling pathways.

• Pituitary Cell Model Research: Investigates its regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and secretion in in vitro cultured pituitary cell lines (e.g., LβT2 cells).

• Endocrine Disruptor Screening: Serves as a positive control for establishing in vitro models to screen environmental compounds for their disruptive effects on the reproductive endocrine system.

• Analytical Method Development: Used as a standard for establishing and validating detection methods such as radioimmunoassay, mass spectrometry, or chromatography.

4. Usage and Storage

• Reconstitution using sterile saline or a specific buffer (e.g., PBS containing 0.1% BSA) is recommended.

• After reconstitution, it should be aliquoted immediately and stored frozen at -20°C or below to avoid repeated freeze-thaw cycles.

• Note: This is a bioactive substance. Appropriate personal protective equipment (PPE) should be worn during handling.

5. Disclaimer
This product is sold solely as a chemical for research purposes and is not authorized for any medical or veterinary use. The purchaser and user must confirm that they are a legitimate research institution or a qualified researcher and commit to not using this product in humans, in vivo animal experiments, drug/dietary supplement development, or for any consumer purposes. The seller expressly disclaims any legal liability and consequences arising from product misuse, including but not limited to its use for hormone regulation, fitness, anti-aging, or similar purposes. This product description does not constitute any medical or health advice.