Adipotide 5mg

Adipotide 5 mg — Research Peptide Technical Information

Adipotide is a synthetic, research‑grade peptide (also called Prohibitin‑TP01, FTPP, or Fat‑Targeted Pro‑Apoptotic Peptide) developed for laboratory investigation into targeted adipose tissue vasculature mechanisms. It is not approved for clinical use and is supplied strictly for in vitro, cellular, or biochemical research purposes.

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1. Product Overview

• Product Name: Adipotide (5 mg)

• Synonyms: Prohibitin‑Targeting Peptide 1, Prohibitin‑TP01, FTPP

• Intended Use: For research purposes only (RUO); not for human or veterinary use.

• Format: White to off‑white lyophilized powder

• Packaging: Sealed vial containing 5 mg net peptide

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2. Molecular & Chemical Specifications

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3. Structure & Domain Architecture

Adipotide is a chimeric peptide composed of two functional parts:

• A targeting/homing domain (CKGGRAKDC) that selectively binds to prohibitin and annexin A2 (ANXA2) receptors expressed on the endothelial cells of white adipose tissue vasculature.

• A pro‑apoptotic domain (D(KLAKLAK)₂) that disrupts mitochondrial membranes once internalized, inducing programmed cell death in the targeted blood vessel cells.

This dual‑domain architecture enables specific interaction and apoptosis induction in adipose tissue vasculature under controlled laboratory conditions.

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4. Mechanism of Action (Research Context)

In scientific models, Adipotide’s mechanism involves:

1. Targeting: The N‑terminal homing sequence binds to prohibitin/ANXA2 receptors on white adipose tissue capillary endothelial cells, directing the compound specifically to sites of adipose vasculature.

2. Cellular Internalization: After receptor engagement, the peptide is internalized into endothelial cells.

3. Apoptosis Induction: The pro‑apoptotic D(KLAKLAK)₂ segment disrupts mitochondrial membranes, triggering intrinsic apoptotic pathways and endothelial cell death.

4. Vascular Regression & Secondary Effects: Loss of blood vessels leads to ischemia of adipose tissue, resulting in adipocyte attrition and reduced adipose mass in preclinical models.

This mechanism is fundamentally research‑oriented and not validated for clinical therapeutic use.

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5. Research Applications

Adipotide is used in laboratory investigations of:

• Adipose tissue vasculature targeting and endothelial cell signaling pathways.

• Mechanistic studies of adiposity and metabolic regulation.

• Apoptosis and mitochondrial membrane disruption research.

• Exploration of prohibitin/ANXA2 receptor biology.

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6. Reconstitution & Handling (For Laboratory Research)

Reconstitution:

• Add sterile water or a compatible buffer to the vial to achieve a desired concentration for in vitro or biochemical assays.

• Gently swirl to dissolve; avoid vigorous shaking to preserve peptide integrity.

Storage:

• Lyophilized powder: Store at ≤ –20 °C in a dry, dark environment.

• Reconstituted solution: Aliquot and store at lower temperatures (≤ –20 °C) if necessary; avoid repeated freeze–thaw cycles.

Safety Handling:

• For research use only; handle in appropriate laboratory conditions using PPE.

• Not for human or veterinary use.

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7. Safety & Regulatory Notes

• Not approved as a pharmaceutical, therapeutic, supplement, or diagnostic agent.

• For research use only (RUO); not intended for human or animal administration.

• Due to its pro‑apoptotic properties and effects on vasculature, rigorous laboratory protocols and safety practices are essential when handling this compound.