AICAR 10mg x 100 tablets

【AMPK Research Tool and Prohibited Sports Substance Declaration】 This product, AICAR (Acadesine, 5-Aminoimidazole-4-carboxamide ribonucleotide), is a small-molecule AMP-activated protein kinase (AMPK) pathway activator research reagent. Important Notice: This compound is explicitly prohibited as a performance-enhancing substance on the World Anti-Doping Agency (WADA) Prohibited List. The product on this page is strictly and singularly defined as a “chemical tool for fundamental research on cellular energy metabolism and signal transduction”. It is not sold as any product for human use, sports enhancement, physical performance improvement, weight management, or disease treatment. Any form of human use, sports application, clinical use, or operation for non-research purposes is strictly prohibited.

1. Product Overview
This product, AICAR, is a classic small-molecule activator of AMPK, a cellular energy status sensor. As a core tool compound for studying cellular metabolic regulation, it is prepared by chemical synthesis and supplied as a white to off-white crystalline powder. It is specifically designed for high-level mechanistic in vitro and preclinical research in cell biology, fundamental metabolic disease research, and physiology, to precisely investigate the activation of the AMPK signaling pathway and its downstream effects under controlled conditions.

2. Key Features

• Defined Research Tool Identity: Provides precise chemical name, molecular formula, and structure, emphasizing its fundamental research purpose.

• High Purity Standard: Verified by High-Performance Liquid Chromatography (HPLC) analysis, with a purity of ≥ 98%.

• Rigorous Quality Control: Structural confirmation via Nuclear Magnetic Resonance (NMR) or Mass Spectrometry (MS), meeting high-specification research reagent standards.

• Solubility and Storage: Soluble in DMSO or water. Recommended for long-term storage in a dry, dark environment at -20°C.

3. Primary Research Applications (Examples – Must be Molecular and Cellular Mechanism Studies)

• Cellular Energy Metabolism Mechanism Studies: In in vitro cultured myotube, hepatocyte, or adipocyte models, serves as a tool compound to quantitatively study the regulatory mechanisms of AMPK activation on processes such as glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and autophagy.

• Metabolic Signaling Pathway Mapping: Used to map phospho-proteomic profiles downstream of AMPK activation or to study its crosstalk with other metabolism-related pathways like mTOR and SIRT1.

• Ischemia/Hypoxia Cell Model Research: In in vitro ischemia/reperfusion or chemical hypoxia models using cardiomyocytes or neurons, explores the effects of AMPK activation on cell survival and apoptotic signaling.

• Drug Discovery Target Validation: In cell-based high-throughput screening, serves as a positive control for validating the activity of novel candidate compounds targeting the AMPK pathway.

4. Usage and Storage

• Preparation of a high-concentration stock solution using cell culture-grade DMSO, followed by dilution to working concentration with appropriate buffer or medium, is recommended.

• Aliquot and store to avoid repeated freeze-thaw cycles. Appropriate personal protective equipment should be worn during handling.

• Extremely Important Warning: Operators must be fully aware of the sensitivity of this product as a prohibited sports substance and commit to using it exclusively for legal, compliant in vitro or preclinical fundamental research, absolutely refraining from any involvement in human or sports-related use.

5. Disclaimer
This product is sold solely as a research probe for exploring fundamental life science questions. The seller is explicitly aware of and opposes any illegal use of it as a sports doping agent or for human enhancement. The purchaser must be a formal academic research institution, university, or the R&D department of a biomedical/pharmaceutical company and must provide relevant institutional proof at the time of purchase. The purchaser must provide a written commitment that the purchased product will be used absolutely and exclusively for legal, compliant in vitro or preclinical fundamental research, and will not, under any circumstances, attempt to use it in any human, any athlete or animal, any sports-related activity, any weight management program, or any unapproved clinical exploration. The seller expressly disclaims and fully excludes any and all legal liabilities (including but not limited to violations of anti-doping regulations), health risks, and ethical disputes arising from the purchaser’s violation of this agreement and any misuse or abuse. This description is solely an explanation of the nature of this compound as a research tool and does not constitute any promise of efficacy or application.