CJC-1295 Whitout DAC

Product Name: CJC-1295 (Without DAC) | Growth Hormone-Releasing Hormone Analog (Short-Acting Pulsatile)

Product Overview
CJC-1295 (Without DAC) is a high-purity, synthetic polypeptide analog of growth hormone-releasing hormone (GHRH, 1-29). Its key characteristic is the absence of a Drug Affinity Complex (DAC), resulting in an extremely short plasma half-life (approximately 30 minutes). This property allows it to mimic the natural pulsatile secretion pattern of endogenous GHRH in research settings, providing a precise tool for investigating the physiological release mechanisms of growth hormone (GH) and its short-term effects.

Technical Specifications

• Sequence: H-Y(2-Me)-A-D-A-I-N-H(2-Me)-A-Q-I(2-Me)-A-R-L-L-N(2-Me)-G-L-V-NH₂

• Molecular Formula: C₁₅₂H₂₄₄N₄₄O₄₂

• Molecular Weight: 3497.9 g/mol

• Purity: ≥ 98% (verified by HPLC analysis)

• Form: White to off-white lyophilized powder

• Storage: Store dry and protected from light at -20°C or lower. After reconstitution, store at 4°C and use within a short period.

Mechanism of Action (Research Use)
This product acts as a GHRH receptor agonist, binding with high affinity to specific receptors in the anterior pituitary gland. Upon binding, it transiently and potently stimulates the pulsatile secretion of endogenous growth hormone (GH). The released GH subsequently promotes the synthesis of insulin-like growth factor-1 (IGF-1) in the liver, thereby mediating research into downstream physiological processes such as protein synthesis, lipid metabolism, and cellular repair.

Core Research Applications
This product is designed exclusively for in vitro and preclinical research. Potential research directions include:

1. Endocrinology Studies: Investigating the regulatory mechanisms and physiological significance of pulsatile GH secretion.

2. Metabolism Research: Analyzing the acute effects of short-term GH pulses on lipid metabolism and glucose homeostasis.

3. Regenerative Medicine Research: Evaluating the effects of GH on tissue repair and regeneration models under simulated physiological rhythms.

4. Sleep and Circadian Rhythm Studies: Given the association between GH secretion and deep sleep, it can be used in related neuroendocrine models.

5. Comparative Pharmacology: Comparing with the long-acting version (CJC-1295 With DAC) to study the differential effects of pulsatile vs. sustained administration modes on biological outcomes.

Important Notes

• Intended Use: This product is for research purposes only. It is strictly prohibited for use in human or animal clinical treatment, diagnosis, or as a dietary supplement.

• Usage Guidelines: Researchers should possess appropriate expertise, operate under suitable laboratory conditions, and adhere to all biosafety and ethical regulations.

• Safety and Disposal: Appropriate personal protective equipment should be worn during handling. All waste materials must be disposed of in accordance with hazardous biochemical waste regulations.

• Quality Statement: We guarantee the product’s specifications and purity at the time of shipment. The stability of the product and the reliability of subsequent research results depend on the user’s storage, reconstitution, and experimental conditions.

Disclaimer: This description is for scientific research and informational exchange only. Any personal attempt to acquire or use this substance carries significant legal and health risks, for which we assume no responsibility. Abnormalities in the human growth hormone system should be addressed through formal medical channels.