NA Selank amidate

Highest Priority Statement: This product is a chemically modified, high-purity synthetic peptide research reagent, strictly for in vitro research use only (For Research Use Only). Modifications such as amidation are solely for investigating fundamental questions in in vitro studies, such as peptide chemical stability and structure-activity relationships. This product is not sold as a pharmaceutical, dietary supplement, or for any consumer purpose. Any use in humans, clinical diagnosis, or non-research applications is strictly prohibited. The purchaser must be a qualified professional researcher and operate in a laboratory environment that complies with all regulations.

1. Product Overview
This product, NA Selank Amidate, is a chemically modified analog of the Selank peptide, typically referring to amidation modification at its C-terminus. Prepared by solid-phase peptide synthesis and supplied in its acetate salt form as a white lyophilized powder, it is designed for high-level in vitro fundamental research in pharmacology and medicinal chemistry. It serves as a tool compound to study the effects of peptide structural modifications (e.g., amidation) on their in vitro physicochemical properties, metabolic stability, and interactions with biological targets.

2. Key Features

• Defined Chemical Modification: Precise molecular weight and the modified amino acid sequence (e.g., Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂, as per the COA) are provided, clearly indicating the amidation site.

• High Purity Standard: Verified by High-Performance Liquid Chromatography (HPLC) analysis, with a purity of ≥ 95%.

• Rigorous Quality Control: Subjected to sterility and low endotoxin testing, meeting high-specification research reagent standards.

• Stable Formulation: Lyophilized powder form, recommended for long-term storage in a dry, dark environment at -20°C.

3. Primary Research Applications (Examples – Must Focus on Fundamental Mechanisms)

• Medicinal Chemistry Structure-Activity Relationship (SAR) Studies: Used as a control compound in in vitro systems to compare the effects of terminal modifications on the binding affinity or functional activity of peptides to specific receptors (e.g., GABA receptor subtypes).

• In Vitro Metabolic Stability Assessment: Used in in vitro models such as liver microsomes, plasma, or recombinant enzymes to quantitatively study how amidation alters a peptide’s resistance to proteolytic degradation.

• Physicochemical Property Analysis: Serves as a standard for analyzing the effects of chemical modifications on in vitro-relevant parameters such as lipophilicity and membrane permeability.

• Signaling Pathway Tool: In highly controlled cell models, serves as a probe to investigate the potential impact of specific structural modifications on the activation patterns of downstream signaling pathways.

4. Usage and Storage

• Reconstitution using a sterile, specific buffer is recommended; the exact solvent should be referenced from relevant literature.

• After reconstitution, it should be aliquoted immediately and stored frozen at -20°C or below to avoid repeated freeze-thaw cycles.

• Note: This is a modified bioactive substance and must be handled by personnel with chemical handling knowledge in a professional environment.

5. Disclaimer
This product is sold solely as a chemical probe for advanced research purposes; its modification serves purely to meet the needs of specific in vitro fundamental research. It is not authorized for any medical, health, enhancement, or consumer use. The purchaser and user must be legitimate research institutions or personnel focused on medicinal chemistry, analytical chemistry, or related fundamental disciplines, and must provide written commitment not to use this product in humans, in vivo animal experiments, any form of consumer product development, or make any direct/indirect medical or efficacy claims (including but not limited to implying “enhanced” or “long-acting” properties). The seller assumes zero responsibility for any uses deviating from this description and for all resulting legal, health, and safety consequences. This description is solely a statement of chemical properties and does not constitute any efficacy or application advice.