PT-141 (Bremelanotide)

Important Statement: This product is a high-purity synthetic peptide research reagent, strictly for in vitro research use only (For Research Use Only). It is the active pharmaceutical ingredient (API) of an approved drug but is not sold here as a pharmaceutical product. Any use in humans, clinical diagnosis, drug formulation, healthcare, or any other non-research purpose is strictly prohibited. The purchaser must be a qualified professional researcher and operate in a laboratory environment that complies with all regulations.

1. Product Overview
This product, PT-141 (Bremelanotide), is a synthetic cyclic heptapeptide belonging to the class of melanocortin receptor agonists. Its chemical structure is specifically designed to serve as a key in vitro tool compound for studying the pharmacological properties of melanocortin receptors, particularly MC4R and MC1R. Supplied in its acetate salt form as a white lyophilized powder, it offers high stability and well-defined composition, prepared specifically for rigorous biochemical and neuroscientific mechanism research.

2. Key Features

• High Purity Standard: Verified by High-Performance Liquid Chromatography (HPLC) analysis, with a purity of ≥ 98%.

• Defined Structure and Sequence: Precise molecular weight (C₅₀H₆₈N₁₄O₁₀·xC₂H₄O₂) and cyclic amino acid sequence are provided to ensure research reproducibility.

• Rigorous Quality Control: Subjected to sterility testing, low endotoxin levels (<1.0 EU/mg), and residual solvent analysis, meeting research reagent standards.

• Stable Formulation: Lyophilized powder form, recommended for long-term storage in a dry environment at -20°C to ensure stability.

3. Primary Research Applications (Examples)

• Receptor Pharmacology Studies: Used for the in vitro evaluation of its selectivity, affinity, and agonist/antagonist activity for melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R).

• Neural Signaling Pathway Research: Serves as a tool compound to study the molecular mechanisms and cellular responses of its activation of downstream signaling pathways such as cAMP/PKA.

• Central Nervous System Research Models: Used to construct in vitro or ex vivo tissue models to explore the role of the melanocortin system in specific physiological processes.

• Analytical Method Development: Can be used as a standard or reference material for establishing and validating analytical methods such as mass spectrometry and chromatographic assays.

4. Usage and Storage

• Reconstitution using sterile saline or a specific buffer is recommended.

• After reconstitution, it should be aliquoted immediately and stored frozen at -20°C or below to avoid repeated freeze-thaw cycles and maintain compound stability.

• Safety Notice: Appropriate personal protective equipment (PPE) should be worn during handling, and operations should be conducted in a professional fume hood or biosafety cabinet.

5. Disclaimer
This product is sold solely as a chemical for research purposes and is not authorized for any medical use. The purchaser and user must confirm that they are a legitimate research institution or a qualified researcher and commit to not using this product in humans, in vivo animal experiments, drug development, or for any consumer purposes. The seller expressly disclaims any legal liability and consequences arising from product misuse, including but not limited to its use, formulation, or sale as a drug. This product description does not constitute any medical advice.