Semax

【Neuroscience Research Tool and Approved Pharmaceutical Ingredient Statement】 This product, Semax (typically referring to N-Acetyl Semax), is a synthetic acetylated hexapeptide research reagent. Important Notice: This compound is an approved prescription drug ingredient in the Russian Federation for specific neurological indications. The product sold on this page is strictly and singularly defined as a “molecular tool for fundamental research in neuroscience and cell biology,” targeting scientific users in non-regulated markets. It is not sold as a pharmaceutical, cognitive enhancer, dietary supplement, or for any consumer purpose. Any use in humans, clinical diagnosis, treatment, or personal enhancement is strictly prohibited.

1. Product Overview
This product, Semax (N-Acetyl Semax), is a synthetic, acetylated analog of the adrenocorticotropic hormone (ACTH) (4-7) fragment. As a research tool in the fields of neuroscience and neuropharmacology, it is prepared by solid-phase peptide synthesis and supplied in its acetate salt form as a white lyophilized powder. It is specifically designed for high-level fundamental mechanistic in vitro and preclinical research in areas related to neuroplasticity, neurotrophic factor signaling, and cellular stress responses.

2. Key Features

• Defined Research Tool Identity: Provides precise molecular weight and acetylated amino acid sequence (Ac-Met-Glu-His-Phe-Pro-Gly), emphasizing its fundamental research purpose.

• High Purity and Stability: Verified by High-Performance Liquid Chromatography (HPLC) analysis, with a purity of ≥ 98%. Acetylation enhances its chemical stability.

• Rigorous Quality Control: Subjected to sterility and low endotoxin testing, meeting high-specification research reagent standards.

• Storage Conditions: Lyophilized powder form, recommended for long-term storage in a dry, dark environment at -20°C.

3. Primary Research Applications (Examples – Must be Mechanistic Fundamental Research)

• Neurotrophic Signaling Pathway Research: In in vitro cultured neuron or glial cell models, serves as a research tool to quantitatively analyze its potential regulatory mechanisms on the expression and signaling activity of brain-derived neurotrophic factor (BDNF) and its receptor TrkB.

• Cellular Protection Model Studies: In in vitro neuronal injury models induced by oxidative stress or toxic substances, explores the molecular pathways through which it affects cell viability, apoptosis markers, or autophagic flux.

• Neuropeptide Metabolism and Stability Research: Used to analyze the effect of acetylation on the resistance of peptides to proteolytic degradation in simulated cell culture environments.

• Fundamental Behavioral Neuroscience Research Tool: In rigorous preclinical animal studies, can serve as a supporting in vitro mechanism research tool to explain the potential cellular and molecular events underlying changes in behavioral phenotypes.

4. Usage and Storage

• Reconstitution using sterile saline or a specific buffer according to published literature methods is recommended.

• After reconstitution, it should be aliquoted immediately and stored frozen at -20°C or below to avoid repeated freeze-thaw cycles.

• Important Warning: Operators must be aware of this product’s drug regulatory status in specific countries and commit to using it solely for legal, compliant in vitro or preclinical fundamental research. Any orientation towards human application is strictly prohibited.

5. Disclaimer
This product is sold solely as a research probe for exploring fundamental neurobiological mechanisms. The seller does not possess pharmaceutical distribution qualifications in the Russian Federation or any other region, and this transaction does not constitute a drug sale. The purchaser must be a legal research institution, university, or the R&D department of a biotech company located outside the Russian Federation and must provide institutional proof. The purchaser must provide a written commitment that the purchased product will be used absolutely and exclusively for legal, compliant in vitro or preclinical fundamental research, and will not, under any circumstances, attempt to use it in any human, any clinical treatment, any cognitive enhancement purpose, or any use that violates the laws and regulations of its location. The seller expressly disclaims and fully excludes any and all legal liability, health risks, and regulatory consequences arising from the purchaser’s violation of this agreement, misinterpretation of its use, or illegal use outside designated regions. This description is solely an explanation of the nature of this molecule as a research tool and does not constitute any medical, efficacy, or application advice.